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Finally, treatment of pregnant rats with the androgen antagonist flutamide eliminates the gender difference in barrier formation These findings suggest that prohibitin may function through BRG1-mediated local chromatin remodeling activity and the removal of pmediated acetylation to produce androgen antagonist-mediated transcriptional repression The animals were subject to castration GOX or ovariectomy OVXestradiol 17β-implantation E2-capsulesand perinatal hormonal treatments with testosterone propionate TP and an androgen antagonist acetate, CA Cells were treated with vehicle DMSO or androgen antagonist flutamide for 2 hours prior to the treatment of the synthetic androgen R for 24 hours
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